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Bactrim is a prescription antibiotic used to treat bacterial infections. It is commonly used to treat UTIs, skin infections, traveler's diarrhea, and bronchitis. Bactrim combines two medications, sulfamethoxazole and trimethoprim, to target and kill the bacteria. Learn about uses, side effects, dosage, and more for Bactrim. It's a prescription oral tablet used to treat certain types of infection in adults and some children. Save up to 80% on your Sulfamethoxazole-trimethoprim prescription at pharmacies nationwide or through prescription delivery starting at $5.